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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

F. Takahashi-Yanaga

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2 papers indexed here

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Open access Sep 2026

OSU-03012 mitigates pulmonary fibrosis by targeting ECM proteins via suppression of S6K-mediated translation and acceleration of MMP-driven clearance.

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease. Currently available anti-fibrotic therapies are limited to slowing lung function decline; however, inducing the resolution of fibrotic lesions remains highly challenging. This study investigated the anti-fibrotic potential and underlying molecular mec...

Kohei Hashimoto, Masaki Arioka, Toshiki Morimoto et al. · 0 citations
Review Aug 2026

The MAPK pathway as a pharmacological target to reprogram cancer-associated fibroblasts and disrupt the stromal shield.

The tumor microenvironment is a complex and dynamic ecosystem composed of a heterogeneous population of non-malignant cells, an extracellular matrix, and diverse soluble factors. Collectively, these elements orchestrate a pro-tumorigenic niche that supports tumor initiation, progression, and metastasis. Within this eco...

Masaki Arioka, F. Takahashi-Yanaga · 0 citations

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