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Open access Sep 2026

Exploring tumorigenesis as a process of phenotypic state-space exploration and selective funneling

Abstract Tumorigenesis is widely studied within evolutionary frameworks, yet integrating genetic, non-genetic, spatial, and collective tumor-level dynamics into a unified description remains challenging. Here, we propose that tumorigenesis can be analyzed as a process in which tumors generate, explore, and filter pheno...

F. Thomas, M. L. Wong, Robert M. Hazen et al. · 0 citations

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