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Open access Oct 2026

Six-year clinical course of depressive and anxiety disorders: analysis by age

Background Evidence on the association between age and the long-term course of affective disorders remains mixed. Objective This study examined the 6-year symptom and diagnostic trajectories of depression and anxiety in relation to age, and assessed whether social, lifestyle, somatic and clinical factors explained obse...

F. Triolo, Laura K. M. Han, H. Jeuring et al. · 0 citations
Open access Sep 2026

Methods for Single and Multilayer Network Analysis for Biomedical Research: The mixmashnet R Package

INTRODUCTIONNetwork medicine provides a framework through which many biomedical phenomena are currently understood, reflecting the multidimensional nature of available data (e.g., genes, diseases, functional parameters). This is particularly relevant in aging research, where aging is driven by interconnected biological...

M. De Martino, F. Triolo, Adrien Périgord et al. · 0 citations
Open access Aug 2026

Multimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial

Preserving independence in older adults is a public health priority. Lifestyle interventions can prevent physical disability, but whether their efficacy is influenced by multimorbidity profiles is unclear. In this post hoc analysis of the SPRINTT randomized trial (NCT02582138), we investigated whether the efficacy of a...

D. L. Vetrano, Caterina Gregorio, F. Triolo et al. · 0 citations
Aug 2026

Prevalent physical multimorbidity patterns and depressive symptom trajectories among community dwelling U.S. older adults.

OBJECTIVES Depression may be accelerated by multimorbidity (≥2 chronic conditions). We used data from the Health and Retirement Study (HRS; 2012-2020) to examine whether trajectories of depressive symptoms varied across prevalent physical multimorbidity patterns among U.S. adults aged ≥65. METHODS Analyses included 9...

Nicholas J. Bishop, Kealie J. Walker, Corey L. Nagel et al. · 0 citations

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