Dysregulated hepatic cholesterol handling and oxidative stress represent key targets for nutritional interventions. This study investigated a combination of Ophiocordyceps sinensis (formerly Cordyceps sinensis) extract and coenzyme Q10 (CoQ10) using a sequential gut–liver in vitro model. Differentiated Caco-2/HT29-MTX...
Age-related skeletal muscle wasting, clinically expressed as sarcopenia and frailty, significantly limits the efficacy of physical rehabilitation due to an underlying cellular bioenergetic decline, mitochondrial dysfunction, and chronic inflammaging. This narrative review synthesizes current physiological and clinical...
Alessio Turco, Lorenzo Lippi, F. Uberti et al.· Dietetics· 0 citations
Autophagy plays a central role in cellular homeostasis and metabolic adaptation, and its dysregulation has been implicated in metabolic disorders, including non-alcoholic fatty liver disease (NAFLD). This study investigated the biological effects of a chemically characterised multi-component nutraceutical formulation u...
Rebecca Galla, Francesca Parini, Simone Mulè et al.· International Journal of Mol...· 0 citations
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