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Open access Jul 2026

Beyond the classical plasma secretome: genetic architecture and disease associations of the expanded human plasma proteome in 13,445 Europeans

Circulating plasma proteins are key biomarkers and therapeutic targets, now measurable at scale through high-throughput technologies, yet whether expanding proteomics platforms beyond the classical plasma secretome enhances genetic discovery and causal inference remains poorly understood. Here, we use an expanded SomaS...

S. Cadiou, E. Konig, A. Mapelli et al. · 0 citations
Open access Nov 2025

SignifiKANTE: efficient P-value computation for gene regulatory networks

Gene regulatory networks (GRNs) are graph-based representations of regulatory relationships between transcription factors and target genes. Various tools exist to infer GRNs from gene expression data, but since this task is computationally intensive, statistical significance estimates are often omitted. While permutati...

F. Woller, Paul Martini, Souptik Sen et al. · 1 citation

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