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Author

F. Zafra

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Open access Oct 2026

Patient iPSC-derived astrocytes reveal impaired homeostasis and reactive-like features in propionic acidemia.

Propionic acidemia (PA) is a neurometabolic disorder caused by propionyl-CoA carboxylase deficiency with frequent neurological involvement, yet cell-type-specific mechanisms remain poorly defined. We established human induced pluripotent stem cell (iPSC)-derived astrocytes (iAs) from patients harboring PCCA or PCCB mut...

Irene González-Garnacho, Mar Álvarez, F. Zafra et al. · 0 citations

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