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Metabolic alterations are increasingly recognized during influenza virus infection, but how local lactate accumulation shapes antiviral immunity remains poorly characterized. By integrating time-series targeted energy metabolomics, single-cell RNA sequencing, flow cytometry, and functional perturbation, we show that in...
Two bivalent multi-epitope mRNA vaccine candidates against M. pneumoniae and C. pneumoniae are designed using an immunoinformatics-based strategy and predicted to be antigenic, non-toxic, non-allergenic, and structurally acceptable.
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