Review
Aug 2026
Immune-mediated excitotoxicity in brain disorders.
The concept of excitotoxicity is extended beyond glutamate receptor overactivation to include innate and adaptive immune pathways, introducing the framework of immune-mediated excitotoxicity and defining three hallmarks - feedback, stressor and chronicity - as organizing principles of this paradigm.
Josef Shin, C. Vogelaar, Stefan Bittner et al.
· Nature reviews. Immunology · 0 citations