Mitochondria-targeted phosphorescent iridium (III) probes for turn-on imaging of selenocysteine dynamics during inflammatory bowel disease.
Irpiq-DNP enabled longitudinal imaging of Sec fluctuations in dextran sulfate sodium (DSS)-induced colitis mice, where the luminescence intensity closely correlated with disease progression as well as therapeutic response to 5-aminosalicylic acid (5-ASA) treatment.