A Brain-Targeted Nanozyme System for Alleviating Poststroke Neuroinflammation via Synergistic Antioxidant and Anti-inflammatory Mechanisms.
Ischemic stroke (IS) is severely aggravated by oxidative stress and neuroinflammation, while the blood-brain barrier (BBB) poses a major obstacle to effective therapy. Herein, we developed a brain-targeted nanozyme system (TLNP@Pt/Fe3O4) by encapsulating Pt/Fe3O4 nanozymes into T7 peptide-modified lipid nanoparticles....