Author

Fa-Xiang Li

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Open access Sep 2026

PTEN-L inhibits mitophagy and GSDME-dependent pyroptosis via Parkin dephosphorylation.

Mitochondrial dysfunction is a potent trigger of inflammatory cell death; however, the precise signaling pathways linking mitochondrial damage to pyroptosis remain incompletely understood. Here, we identify a previously unrecognized pathway in which mitochondrial depolarization activates the PINK1-Parkin axis to drive...

Cheng-Hao Yan, Cai-Nian Huang, Xu Liu et al. · EMBO Reports · 0 citations

Open access Jul 2026

X-linked SYTL4 missense variant disrupts RAB27A-dependent vesicle trafficking and synaptic transmission in autism.

The findings implicate disrupted SYTL4-RAB27A-dependent vesicle trafficking in ASD pathogenesis and identify SYTL4 and RAB27A as previously unrecognized contributors to autism-associated synaptic deficits and behavior.

Yang Liao, Shuju Zhang, Xiaolei Zhang et al. · Proceedings of the National... · 0 citations