Open access
Aug 2026
STX1B variant-specific synaptic dysfunction is associated with network hyperexcitability in human iPSC-derived neurons
The divergence between morphological, electrophysiological and transcriptomic findings suggests that compensatory mechanisms may contribute to network hyperexcitability, and the graded severity of network alterations across STX1B variants correlates with the clinical phenotypes.
Carolin Haag, Felix Gsell, Oleg Vinogradov et al.
· EBioMedicine · 0 citations