Open access
Sep 2026
Computational Studies of the Dynamics of the Human Iron Exporter Ferroportin and Insight into the Role of Crucial Residues Involved in Pathogenic Mutations
Ferroportin (FPN/SLC40A1), the only known human iron exporter, plays a key role in iron homeostasis through an alternating access mechanism involving inward–open, occluded, and outward–open conformations. Pathogenic FPN mutations cause ferroportin–related iron overload, an autosomal dominant iron overload disease chara...
Sergio Vulterini, Maria Carmela Bonaccorsi di Patti, Giovanni Musci et al.
· Biomolecules · 0 citations