Abstract A038: LINE-1 remodel pancreatic ductal adenocarcinoma metastatic plasticity
Retrotransposons comprise most of the human dark genome and are frequently upregulated during cancer progression. Long interspersed nuclear element-1 (LINE-1), the only autonomously active human retrotransposon, is aberrantly reactivated in pancreatic ductal adenocarcinoma (PDAC), yet how LINE-1 regulates metastatic...