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Author

Fan Chen

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Open access Oct 2026

D-allose reprogrammes the mitophagy-mtDNA-cGAS-STING-ADM2 axis to restore nucleus pulposus cell homeostasis in intervertebral disc degeneration.

Intervertebral disc degeneration (IVDD) is driven by progressive loss of nucleus pulposus cell (NPC) homeostasis, yet the stress-responsive mechanisms governing this process remain incompletely defined. Here, we identify a mitochondrial stress-innate immune signalling axis in which impaired mitophagy promotes mitochond...

Zhuo-Yang Zhao, Jia-Min Li, Lin-Chuan Lei et al. · 0 citations

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