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Open access Sep 2026

Complement C5 inhibitor as a rescue therapy for acute NMOSD attacks: a multicenter retrospective cohort study in China

Background Complement activation plays a key role in the pathogenesis of neuromyelitis optica spectrum disorder (NMOSD). While eculizumab effectively prevents relapses, its role in acute attacks remains uncertain. Methods We retrospectively analyzed 38 patients with acute NMOSD treated with eculizumab across seven tert...

Tao Wu, De-Cai Tian, De-Hui Huang et al. · 0 citations
Aug 2026

Rapid clinical stabilization following eculizumab therapy in severe anti-NMDAR encephalitis.

Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis is a potentially severe autoimmune encephalitis that may rapidly progress to critical illness. We report a young patient with severe anti-NMDAR encephalitis complicated by seizures, psychiatric symptoms, behavioral disturbance, dyskinesia, and dysautonomia. Despit...

Yang Liu, Yu-Jing Yuan, Yingjie Zhang et al. · 0 citations

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