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Author

Fan Liu

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2 papers indexed here

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Open access Oct 2026

Activation of CaMKIIα regulates hippocampal mitochondrial metabolism and attenuates neuroinflammation: A novel therapeutic target for obesity-associated neurocognitive disorders.

ABSTRACT Obesity is strongly associated with cognitive impairment, especially in memory. However, the underlying molecular mechanisms remain unclear. Ca2+/calmodulin-dependent protein kinase II (CaMKII), a key synaptic kinase, regulates synaptic plasticity and hippocampal memory function through N-methyl-D-aspartate re...

Fan Liu, Chen Chen, Yu-Bing Zeng et al. · 0 citations
Aug 2026

Tet1-mediated 5-hydroxymethylcytosine alterations in the olfactory bulb are associated with aberrant neurogenesis and PI3K-Akt signaling in response to CIH.

Tet1 knockdown in the OB partially normalized PI3K-Akt signaling, was associated with improved neurogenesis markers, and alleviated CIH-induced olfactory dysfunction, suggesting that Tet1 may serve as a potential therapeutic target for CIH-related sensory impairment.

Yaru Kong, Yuwei Qi, Jiajia Dong et al. · 0 citations

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