Author

Fan Wang

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Open access Jul 2026

Cross-genus analysis reveals architecturally programmed sgRNA synthesis patterns in coronaviruses.

It is shown that canonical sgRNA formation is associated with same-direction RNA-RNA interactions, and this finding highlights a potential link between non-canonical sgRNAs, genomic plasticity, and immune modulation, which may have implications for coronavirus adaptation.

Zi Wen, Lei Chen, Dehua Luo et al. · Molecular Systems Biology · 0 citations

Open access Aug 2026

A computational framework integrating a protein language model with alchemical simulation for gain-of-function enzyme design.

The ESM-FEP framework establishes a generalizable and efficient strategy for the rational design of gain-of-function enzymes, with broad applications in biocatalysis, bioremediation, and precision agriculture.

Long-Can Mei, Jian Wu, Li-Jun Chen et al. · Plant Communications · 0 citations