FK506-mediated prevention of noise-induced hearing loss is associated with attenuated ER stress responses.
Noise-induced permanent hearing loss results primarily from the irreversible loss of cochlear sensory hair cells, which do not regenerate in adult mammals. Endoplasmic reticulum (ER) stress may play a major role in noise-induced outer hair cell (OHC) loss. We previously reported that FK506 prevents noise-induced hearin...