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Author

Fan-Xuan Huang

2 papers indexed here

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Oct 2026

Discovery of Diaryl Pyrimidine-Guanidine Derivatives as Jumonji C Domain-Containing Lysine Histone Demethylase (KDM) Inhibitors with In Vivo Anti-Cervical Cancer Activity

JMJD family histone demethylases are highly expressed in cervical cancer and promote tumor progression, highlighting their potential as therapeutic targets for this malignancy. Using a scaffold-hopping-based virtual screening, we discovered a series of diaryl pyrimidine-guanidine derivatives as KDM6B inhibitors. The...

Dong-Xuan Ni, Ting Wang, Ji-Jian Yang et al. · 0 citations
Open access Sep 2026

Single-cell transcriptomic analysis identifies vascular smooth muscle cell transcriptional programs associated with human carotid plaque remodeling

Vascular smooth muscle cells (VSMCs) contribute to plaque structure and exhibit diverse transcriptional programs in human atherosclerosis. Although human plaque single-cell studies have established substantial VSMC heterogeneity, an important unresolved question is whether discovery-defined programs remain recogniz...

Yi-Jie Lu, Xue-Guang Lin, Ting Wang et al. · 0 citations

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