Discovery of Diaryl Pyrimidine-Guanidine Derivatives as Jumonji C Domain-Containing Lysine Histone Demethylase (KDM) Inhibitors with In Vivo Anti-Cervical Cancer Activity
JMJD family histone demethylases are highly expressed in cervical cancer and promote tumor progression, highlighting their potential as therapeutic targets for this malignancy. Using a scaffold-hopping-based virtual screening, we discovered a series of diaryl pyrimidine-guanidine derivatives as KDM6B inhibitors. The...