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Preprint Aug 2026

Learning latent progression states from spatial heterogeneity in uterine histopathology

Tumor progression is accompanied by changes in architecture, morphology and microenvironmental organization, yet progression-associated heterogeneity is usually compressed into static diagnostic categories in histopathology. Here we present SpaTIE, a uterus-specific computational pathology framework that learns morphol...

Qi-Ming He, Yan Liu, Shuang Ge et al. · 0 citations
Open access Aug 2026

BraMARS: An Interpretable Histopathology‐Driven Deep Learning Model for Brain Metastasis Risk Stratification in Surgically Resected Limited‐Stage SCLC

Overall, BraMARS provides a biologically interpretable histopathology‐based framework for estimating subsequent BM risk in resected LS‐SCLC, with potential to support individualized intracranial risk assessment, intensified MRI surveillance, and hypothesis generation for prospective BM‐prevention strategies.

Zi-Jian Yang, Taolue Wang, Shilong Liu et al. · 0 citations

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