Open access
Sep 2026
Perspectives on the Nutritional Paradox in Uremia: A “Sensitize-Then-Feed” Framework for Protein-Energy Wasting
A model in which gut-microbiome–derived uremic toxins, notably tryptophan metabolites, have been shown in experimental models to impair the blood–brain barrier integrity is proposed, and a translational “sensitize-then-feed” therapeutic paradigm is advocated.
Mao-Ting Li, Ze-Wei Chen, Nan-Mei Liu et al.
· Advances in Nutrition · 0 citations