Fang Dong

P-selectin delineates conserved functional heterogeneity in early hematopoietic stem cell aging in humans and mice

Progressive aging of bone marrow hematopoietic stem cells (HSCs) underlies clonal hematopoiesis and age-associated hematologic disorders. Defining early molecular events driving HSC functional decline is essential for rejuvenation strategies. Here, we identify P-selectin (Selp) as a surface marker that stratifies HSCs...

KLF4/MLL3 complex axis drives NRBP2 transcription to eliminate acute myeloid leukemia cells.

Engineered lipid nanoparticles for in vivo and durable editing of haematopoietic stem cells within humanized mice.

An LNP is reported that efficiently delivers reporter mRNA to human HSPCs both in ex vivo and in vivo settings when conjugated with the anti-CD34 antibody (CD34/LNPDP).