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Open access Oct 2026

Neuronal progranulin in the medial prefrontal cortex mediates stress-induced despair-like behaviors and impaired neuroplasticity.

BACKGROUND Neuroplasticity in the medial prefrontal cortex (mPFC) is critically implicated in major depressive disorder (MDD). Progranulin (PGRN), a multifunctional protein that is abundant in the cortex, regulates neuronal development and synaptic maintenance, positioning it as a candidate therapeutic target for MDD....

Yun-Feng Wang, Yao Yang, Si-Man Guo et al. · 0 citations
Open access Jul 2026

Treatment effects on sphingosine-1-phosphate and its receptors in major depressive disorder: implications for biomarkers

The data demonstrate a significant, sex-dependent dysregulation of the peripheral S1P signaling pathway in MDD, which is responsive to antidepressant treatment, implying that the S1P pathway plays a crucial role in the pathophysiology of depression.

Xiao Yang, Le Wang, A. Jiang et al. · 0 citations

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