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Open access Oct 2026

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we introduce an integrated platform with three nove...

Zhi-Peng Ling, Jun-Ping Pan, Xiang-Lu Xiao et al. · 0 citations
Open access Sep 2026

Alzheimer's disease diagnosis based on gene selection and cross-tissue validation.

Background Early and accurate diagnosis is critical for intervening in the progression of Alzheimer's disease (AD). However, traditional clinical diagnostic techniques, such as invasive cerebrospinal fluid punctures and expensive neuroimaging, struggle to meet the demands of large-scale early screening. Methods This...

Xiao-Lan Zhang, Xiao-Tong Tang, Qian Bo et al. · 0 citations

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