Single-cell RNA sequencing uncovers m6A regulator-defined T-cell subpopulations and YTHDF1-HSP90AB1-MYC therapeutic axis in T-cell acute lymphoblastic leukemia.
BACKGROUND N6-methyladenosine (m6A) drives T-cell acute lymphoblastic leukemia (T-ALL); however, its roles in leukemic heterogeneity and tumor microenvironment remodeling unclear. This study characterized N6-methyladenosine regulator-defined subpopulations and YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) in le...