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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Fang Xiao

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2 papers indexed here

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Open access Aug 2026

A generalizable covalent car-t platform for solid tumors enabled by oncolytic adenovirus-delivered artificial antigens

Background Chimeric antigen receptor (CAR) T-cell therapy has shown limited efficacy against solid tumors due to antigen heterogeneity and scarcity of tumor-specific targets. Methods To address those challenges, we report a covalent CAR-T strategy that achieves programmable tumor recognition via oncolytic adenovirus-me...

Lin-Pei Guo, Hui Xie, Di Yin et al. · 0 citations
Sep 2026

BRD2-Mediated TGR5 Destabilization Impairs Fatty Acid Oxidation and Drives Tubular Ferroptosis in Diabetic Kidney Injury.

A BRD2-TGR5-FAO signaling axis is delineated as a central pathogenic driver of tubular lipotoxicity and ferroptosis in diabetic kidney injury, and BRD2 inhibition is position as a mechanistically grounded therapeutic strategy for diabetic kidney disease.

Hui-Mei Zang, Fu-Cheng Zang, Hai-Yan Zhang et al. · 0 citations

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