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Evidence is provided for a novel UCA1 interaction regulatory network in bladder cancer, that is, UCA1-miR-582-5p-ATG7-autophagy axis, which provides a new insight into the treatment of bladder cancer.
This work identifies alanyl tRNA synthetase 1 (AARS1) as a clinically relevant driver of aggressive and recurrent BC and defines an AARS1 associated metabolic and epigenetic program in BC and nominate AARS1 targeting strategies as a direction for further therapeutic development.
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