Preprint
Oct 2026
Beyond the Transcriptome: Chromatin-Informed Prediction of Cell-State-Dependent Perturbation Responses
Predicting transcriptional responses to genetic perturbations is central to understanding gene function. Existing predictors primarily rely on transcriptomic measurements, although chromatin accessibility provides complementary information about the cellular context in which perturbations act. Using this information re...
Jia-Fa Ruan, Chen-Yan He, Rui-Jie Quan et al.
· 0 citations