Author

Fangmei Zhou

3 papers indexed here

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Sep 2026

Anti-inflammatory activity and structure-function analysis of degraded polysaccharide fragments from Tetrastigma hemsleyanum.

Tetrastigma hemsleyanum Diels et Gilg (T. hemsleyanum) is a medicinal plant with immunomodulatory activity. Its acidic glucuronic acid galactomannan (STHP5, 128 kDa) is degraded into fragments STHP5 DF-1 (78 kDa, helical, 2,3-Manp backbone, the main active fragment). STHP5 DF-1 inhibited NO and inflammatory cytokines,...

Ya-Fei Li, Kui-Xu Gao, Shuang-Yi Zhang et al. · International Journal of Bio... · 0 citations

Aug 2026

Tetrastigma hemsleyanum polysaccharides ameliorate inflammatory bowel disease via sphingosine-1-phosphate/sphingosine-1-phosphate receptor 2 -mediated gut vascular barrier repair.

It is demonstrated that THP alleviates IBD by repairing the GVB through the S1P/S1PR2 axis, providing a mechanistic basis for GVB-targeted therapeutic strategies.

Wenxuan Li, Yi-Wen Hu, Menghan Yang et al. · Phytomedicine · 0 citations

Open access Jul 2026

Colon-targeting pH-responsive Bletilla striata polysaccharide coacervate microdroplets for ulcerative colitis therapy via macrophage reprogramming

Ulcerative colitis (UC) is an immune-mediated chronic inflammatory bowel disease that severely impairs patients’ quality of life. Efficient oral colon-targeted delivery systems are urgently needed to improve local therapeutic efficacy while minimizing systemic exposure. Herein, we developed a pH-responsive Eudragit S10...

Qiantao Zhang, L. Chai, Hui Liu et al. · Journal of Nanobiotechnology · 0 citations