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Author

Farah Kobaisi

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Open access Sep 2026

Engineering the insulin signal peptide to protect human pancreatic beta cells from autoimmune destruction.

Beta cells expressing insulin with chromogranin-A signal peptide evaded recognition and killing by autoreactive T cells without inducing ER stress or compromising cellular identity, and may offer a targeted alternative to systemic immunosuppression to be used in stem-cell-derived therapies by engineering endogenous ins...

Farah Kobaisi, Masaya Oshima, Zhi-Cheng Zhou et al. · 0 citations

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