Synergistic reversal of mesenchymal stem cell senescence by engineered exosomal delivery of a dual miR-195/miR-188 sponge.
BACKGROUND Cellular senescence critically impairs the regenerative potential and therapeutic efficacy of adipose-derived mesenchymal stem cells (AD-MSCs). MicroRNAs miR-195 and miR-188 are key regulators of aging-associated pathways, making them attractive nucleic acid targets for senescence modulation. In this study,...