Hippocampal Klotho Expression Is Associated with the Neuroprotective Effects of Metformin Against ICV-STZ-Induced Cognitive Deficits.
Alzheimer's disease (AD) is characterized by progressive cognitive decline, amyloid-β (Aβ) accumulation, oxidative stress, and neuroinflammation. Increasing evidence links metabolic dysfunction to AD, suggesting that antidiabetic drugs such as metformin may exert neuroprotective effects. This study investigated the eff...