Open access
Oct 2026
In silico design of novel indolinone-based anticancer agents and proposal of synthetic routes
The RAF–MEK–ERK signaling pathway plays a central role in cancer development and progression and represents an important target for anticancer drug discovery. Simultaneous targeting of components of this pathway may therefore represent a promising strategy for cancer treatment. A quantitative structure-activity relatio...
M. Er-rajy, Mohamed El Fadili, Hanane Etabti et al.
· Frontiers in Bioinformatics · 0 citations