Author

Fawaz G. Haj

2 papers indexed here

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Review Open access Sep 2026

The role of classical protein tyrosine phosphatases in diabetic kidney disease and therapeutic implications

Approximately one-third of people with diabetes have diabetic kidney disease (DKD), and DKD remains a leading cause of kidney failure in the United States. DKD is characterized by injury to the glomerular filtration barrier and renal tubulointerstitium, arising from complex and convergent metabolic, hemodynamic, and in...

Grace LeBleu, F. Haj · Journal of Biomedical Scienc... · 0 citations

Open access Aug 2026

Deletion of protein tyrosine phosphatase 1B in hepatocytes attenuates inflammation, steatosis, and fibrosis in a dietary mouse model of metabolic dysfunction-associated steatohepatitis

Metabolic dysfunction-associated steatohepatitis (MASH) is a leading cause of liver-related morbidity and mortality. The current interventions are limited, underscoring the need for novel mechanism-based therapies. Protein tyrosine phosphatase 1B (PTP1B) regulates phosphotyrosine signaling and hepatic metabolism,...

Ming-Fo Hsu, Yoshihiro Ito, Ulrik N. Mjaaseth et al. · Molecular Medicine · 0 citations