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Federico Canavese

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Open access Jul 2026

Comparison of responses from large language models using artificial intelligence for parent-focused inquiries on clubfoot treatment and Ponseti management

This study aimed to compare the accuracy, completeness, and readability of responses generated by three large language models (LLMs)—ChatGPT-4.0 (OpenAI), Microsoft CoPilot, and Google Gemini—regarding the treatment and management of idiopathic congenital talipes equinovarus (ICTEV) using the Ponseti method. Fifteen frequently asked questions were selected from pediatric orthopedic center websites, Google Trends analysis, and clinical experience. Each question was submitted verbatim in a new session to the three LLMs within 24 h. Seven board-certified pediatric orthopedic surgeons, blinded to the source, rated responses for accuracy (5-point Likert scale) and completeness (3-point Likert scale). Readability was assessed using the Flesch–Kincaid grade level. Mean scores ± standard deviation were calculated, and inter-rater reliability was estimated using the intraclass correlation coefficient (ICC). Group differences were tested with ANOVA and chi-squared tests ( p  < 0.05). A total of 45 responses were evaluated. Gemini achieved the highest mean accuracy (4.1 ± 0.8), followed by CoPilot (3.6 ± 0.8) and ChatGPT-4.0 (3.3 ± 0.9), with significant differences among models ( p  < 0.001). Completeness ratings also differed significantly ( p  < 0.001). Readability analysis showed that ChatGPT produced shorter, more readable text, while Gemini generated longer, more complex responses. Inter-rater reliability was substantial for accuracy (ICC 0.715) and completeness (ICC 0.710). Google Gemini outperformed ChatGPT-4.0 and CoPilot in accuracy and comprehensiveness for ICTEV management using the Ponseti method. However, its complex responses may limit accessibility, whereas ChatGPT-4.0 offered more readable but less detailed answers. IV

A. Vescio, G. Testa, M. Sapienza et al. · 0 citations