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Open access Oct 2026

Epigenetic Silencing of CYYR1 Promotes Lung Adenocarcinoma Progression Through TRIM21‐Dependent Regulation of HMMR Stability

ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer‐related mortality. Integrative multi‐omics and machine‐learning analyses across independent cohorts identified CYYR1 as a frequently downregulated transmembrane protein in LUAD, with low expression associated with poor prognosis and promoter hypermet...

Feng-Sheng Dai, Jing-Yi Tang, Huan Rong et al. · 0 citations
Review Open access Aug 2026

CRISPR technologies for detecting DNA and RNA methylation: Mechanisms, platforms, and translational opportunities

Abstract DNA and RNA methylation are key epigenetic and epitranscriptomic modifications involved in gene regulation, genome stability, RNA metabolism, and disease progression. Aberrant methylation patterns in cell‐free DNA and RNA have emerged as valuable biomarkers for cancer detection, disease monitoring, and therape...

Kai-Xin Chen, Bi-Yao Yang, Rui Sang et al. · 0 citations

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