Discovery of Novel Cyanoacrylates as Potential Myosin I Inhibitors with Remarkable Activity against Fusarium Species.
Fusarium head blight (FHB) is a devastating wheat disease causing yield losses and mycotoxin contamination. Phenamacril, a myosin I-targeting fungicide, has a limited antifungal spectrum. Using structure-based drug design focusing on M375 in Fusarium graminearum myosin I (FgMyoI), we synthesized 25 phenamacril derivati...