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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Fei Zhang

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Sep 2026

SGK2 Promotes NEDD4L-Mediated ACSL4 Ubiquitination to Inhibit Ferroptosis and Alleviate Diabetic Kidney Disease.

It is found that SGK2 suppresses tubular ferroptosis in DKD through NEDD4L-dependent K48-linked ubiquitination and proteasomal degradation of ACSL4, thereby limiting lipid peroxidation and protecting the renal tubules.

Fei Zhang, An-Dong Zhang, Li-Wen Wang et al. · 0 citations

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