Open access
Aug 2026
Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism.
Interferon-stimulated gene 15 (ISG15) encodes a ubiquitin-like protein that regulates diverse cellular responses, including antiviral immunity, through its conjugation to proteins in a process known as ISGylation. Several pathogens, including SARS-CoV-2, subvert ISGylation by encoding deISGylating enzymes. However, the...
Jun-Ji Zhu, Guan-Qun Liu, Jie-Lin Xu et al.
· Immunity · 0 citations