Author

Felix J. Hartmann

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Open access Jul 2026

FGFR2 fusion-driven cholangiocarcinoma is characterized by a distinct neutrophil-enriched tumor microenvironment in a syngeneic murine model.

The syngeneic murine Ff-iCCA model is introduced, providing a platform for functional investigation of cancer cell-TME crosstalk in this molecular subtype, and overcoming the key limitation of prior models relying on human transgenes in immunodeficient hosts.

N. Lekiashvili, Trinh Kieu Dinh, Alexander Olkus et al. · JHEP Reports · 1 citation