Author

Felix L. Struebing

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Open access Aug 2026

Molecular Disease Stages of Oligodendrocytic and Neuronal Tau Burden in Progressive Supranuclear Palsy

Background Progressive supranuclear palsy (PSP) is a primary tauopathy defined by the accumulation of 4R tau isoforms in neurons, oligodendrocytes and astrocytes. Despite evidence of genetic susceptibility operating through glial cell types, it remains poorly understood how cell type-specific epigenetic-transcriptional...

N. Briel, Viktoria C. Ruf, Paul L. C. Feyen et al. · bioRxiv · 0 citations

Open access Jul 2026

Spatial multi-omics identifies early synaptic pruning and context-specific dopaminergic vulnerability in synucleinopathies

It is shown that early complement associated pruning of inhibitory synapses precedes overt α-synuclein aggregation and neuronal loss in prodromal synucleinopathy, indicating disease-context dependent relationships between αSyn pathology and neurodegeneration.

Svenja-Lotta Rumpf, Felix L. Strübing, Karsten Nalbach et al. · Nature Communications · 0 citations