Open access
Oct 2026
CDK2/9 blockade remodels chromatin and drives phenotypic plasticity in glioblastoma organoids
Glioblastoma (GBM) remains a highly lethal brain tumor with limited therapeutic options and pervasive resistance to standard treatments. Cyclin-dependent kinases (CDKs), key regulators of cell cycle progression and transcription, are frequently dysregulated in GBM and contribute to tumor pathogenesis. We employed a ran...
P. Kaps, A. Hieltscher, Andrea Auditore et al.
· Cell Communication and Signa... · 0 citations