Author

Feng Cao

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Open access Sep 2026

Single-cell RNA sequencing reveals PANoptosis signatures of acinar cells, macrophages, and neutrophils during injury and repair in acute pancreatitis

Background Acute pancreatitis (AP) involves acinar cell injury, inflammation, and tissue remodeling. Although regulated cell death pathways contribute to AP progression, the cell type-specific features and dynamics of PANoptosis remain unclear. This study aimed to characterize PANoptosis-associated signatures in pancre...

Wei-Zhi Zhang, Feng Cao · Frontiers in Cell and Develo... · 0 citations

Open access Sep 2026

Targeting p38α promotes Parkin-mediated mitophagy to attenuate severe acute pancreatitis via suppressing the mtDNA/cGAS-STING signaling pathway

This study illuminates a novel role of the p38α/Parkin/mtDNA/cGAS-STING signaling axis in the pathogenesis of SAP, and highlights targeting the p38α-mediated Parkin S131 phosphorylation switch as a promising therapeutic strategy for clinical intervention against SAP.

Xiao-Zhou Xie, Jie Li, Hao-Yu Zhang et al. · Cell Death & Disease · 0 citations