Metabolic targeting by a small extracellular vesicle-based cellulose-GelMA hydrogel restores neurovascular regeneration in diabetic nerve injury
Diabetic peripheral nerve injury (PNI-DM) causes severe sensory and motor dysfunction, yet the metabolic mechanisms impairing neurovascular repair remain unclear. Using histological and molecular analysis of human nerve and muscle tissues, we observed pronounced methylglyoxal-derived hydroimidazolone-1 (MG-H1)/methylgl...