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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Feng-Hua Wang

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Sep 2026

Channel-Guided Engineering of Tryptophan Synthase β-Subunit for High-Level Biosynthesis of the Garlic Bioactive Compound S-Allyl- l -Cysteine

S-Allyl-l-cysteine (SAC) is a bioactive organosulfur compound from aged garlic that has attracted considerable interest for its health-promoting properties. Here, we developed a channel-guided engineering strategy to enhance SAC biosynthesis using the β-subunit of tryptophan synthase (TrpB). Genome mining guided by c...

Zhao-Lin Song, De-Quan Liu, Zhao Zhang et al. · 0 citations
Sep 2026

Ancestral Sequence Reconstruction Synergized with Deep Learning Significantly Enhances the Thermophilicity and Thermostability of the Highly Active Alkaline Protease AprE

Although alkaline proteases have broad industrial applications, their practical use is hindered by insufficient thermostability and limited strategies to elevate optimal catalytic temperature (Topt) while retaining catalytic activity. To enhance Topt and thermostability of Bacillus clausii AprE without sacrificing ca...

Yi-Min Cai, Ya-Rui Bian, Yu-Ying Chen et al. · 0 citations

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