NEUROLOGY AND PRECLINICAL
Qiu-Ju Shen, Yi-Xin Zhao, Feng-Tao Liu et al.
· 0 citations
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Open access
Aug 2026
Cholesterol enhances lysosome-autophagosome fusion for better α-synuclein clearance in GBA L444P-mutated Parkinson disease.
It is reported, in a large cohort, that GBA-mutated PD patients exhibit lower serum cholesterol levels and cholesterol supplementation was found to enhance the autophagic flux and mitigate α-synuclein accumulation in vitro, whereas AAV-Srebp2 delivery increased α-synuclein clearance in GbaL444P/+ mice.
Mingjia Chen, Feng-Tao Liu, Yu-Jie Yang et al.
· Cell Reports · 0 citations