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Author

Fenglei Chen

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Open access Oct 2026

Neuromedin B Regulates Cell Proliferation, Apoptosis and Steroidogenesis of Porcine Ovarian Granulosa Cells via NMBR

Granulosa cells (GCs) critically govern follicular development through the coordinated regulation of proliferation, apoptosis, and steroidogenesis. Neuromedin B (NMB), a local regulatory peptide, has been implicated in female reproductive processes. However, its precise effects on porcine GCs remain to be elucidated. I...

Zhi-Yu Ma, Hong-Xia Li, Guang-Zhen Chen et al. · 0 citations
Aug 2026

Effects and mechanisms of NMB knockdown on cell proliferation, apoptosis and steroidogenesis in porcine ovarian granulosa cells.

Findings suggest that NMB may serve as an important regulator of cell viability, apoptosis and steroidogenesis through mitochondrial Ca2+ uptake and the PKA/CREB axis in GCs, thereby providing new mechanistic insights into follicular development and potential targets for improving porcine reproductive efficiency.

Hongxia Li, Guang-Zhen Chen, Jia Li et al. · 0 citations
Aug 2026

Precise dual-gene knockout of MSTN and SOCS2 via cytidine base editing enhances muscling and growth in goats

This study successfully established a YE1-AncBE4max-based platform for efficient, precise dual-gene editing in goats and showed that the edited goats exhibited significantly increased body weight and a "double-muscling" phenotype by 90 days of age compared to wild-type controls.

Ling Li, Ming-Xing Cao, Muhammad Farhab et al. · 0 citations

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