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Flavia Pivetta

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Open access Jul 2026

TWIST1 bridges p53 and MDM2 and impairs the efficacy of MDM2 inhibitors

Targeting TWIST1 restores p53 pathway activation and sensitizes sarcoma cells to MDM2 blockade, establishing TWIST1 as a promising predictive biomarker and therapeutic vulnerability for improving MDM2i efficacy.

S. Piccinin, Bernadetta Szaboova, Flavia Pivetta et al. · 0 citations

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