Author

Florence M. Cammas

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Open access Jul 2026

TRIM28 PRESERVES OVARIAN IDENTITY BY STABILIZING LINEAGE-SPECIFIC TRANSCRIPTION FACTOR HUBS

These findings identify TRIM28 as a central organizer of ovarian TF hubs whose predominant function is to preserve granulosa cell identity through stabilization of lineage-specific TFs rather than H3K9me3-dependent heterochromatin.

Laura Sitkiewicz, Florian Chaleil, Gaby Granès et al. · bioRxiv · 0 citations

Open access Aug 2026

Isotype specific loss of HP1α but not of HP1β uncovers genomic regions that behave as HP1α-dependent common fragile sites

Data indicate that, independently of its binding to H3K9me3, HP1α stabilizes specific genomic regions that behave as HP1α-dependent fragile sites, at least in part by regulating replication fork progression, limiting mitotic DNA synthesis possibly by competing with FANCD2 for chromatin access at these regions.

Katherine Yaacoub, Thanh Nhàn Nguyễn, Eric Julien et al. · bioRxiv · 0 citations